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The latest generation of dementia research

Dr Laura PhippsKirsty MaraisClaire LucasRobin BrisbourneKaty StubbsEd PinchesGlyn Morris

As Dementia Awareness Week approaches, BBC Horizon has thrown a spotlight onto dementia research with their latest programme featuring recent advances in the field. One of the studies discussed in this programme was a large research study looking at ways of helping people to live well with dementia. This study, called the GREAT trial, focused […]

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Epigenetics and its role in Alzheimer’s disease

Ally Matthews

One of the best ways to understand the genetics underlying Alzheimer’s disease is through large DNA studies. These studies are known as genome-wide association studies (GWAS) and involve analysing the genetic make-up of people with and without Alzheimer’s or other causes of dementia, in great detail. GWAS studies have ‘flagged up’ different versions of certain […]

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The orchestral brain

Dr Dervis Salih

Imagine an orchestra playing a complex and beautiful symphony. And now imagine there are 25,000 musicians in the orchestra. This is one way to picture how our genes work together to control the function of our brains. Mammals have around 25,000 genes, and so this takes some coordination. In people with Alzheimer’s, and other causes […]

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TREM2: Where are we now?

Dr Laura PhippsKirsty MaraisClaire LucasRobin BrisbourneKaty StubbsEd PinchesGlyn Morris

Yesterday, Dr Rita Guerreiro was awarded the great honour of European Researcher of the Year, fighting off stiff competition from dementia researchers across the continent. This fantastic achievement recognised her groundbreaking discovery in 2012; variations in the DNA code of a gene involved in immune system regulation, called TREM2, can increase the risk of Alzheimer’s […]

How large DNA banks help us to defeat dementia

Dr Laura PhippsKirsty MaraisClaire LucasRobin BrisbourneKaty StubbsEd PinchesGlyn Morris

Alzheimer’s Research UK recently awarded a £96,000 grant to Prof Kevin Morgan at the University of Nottingham to maintain and expand his large collection of DNA samples. This is to ensure he can continue his important research into the genetics of Alzheimer’s disease. These huge DNA banks are an essential tool for Alzheimer’s research; the […]

In the news: The genetics of Alzheimer’s risk

Dr Laura PhippsKirsty MaraisClaire LucasRobin BrisbourneKaty StubbsEd PinchesGlyn Morris

Making the news today is research from scientists at Cardiff University who, as part of a global research team, have discovered 11 new areas of the genome linked to a higher risk of Alzheimer’s. The study is unique in the field of Alzheimer’s, not just for the sheer quantity of genetic information it has produced […]